4 edition of Exploring the Polar Regions (Voyages of Discovery) found in the catalog.
|LC Classifications||August 31, 1997|
|The Physical Object|
|Pagination||xvi, 79 p. :|
|Number of Pages||86|
nodata File Size: 3MB.
Northern Antiquities or An Historical Account of the Customs and Practices of the Ancient Scandinavians 1847
Therefore, Spain sought to enforce their rights in the Moluccan islands, which led a conflict with the Portuguese, but the issue was resolved with the Treaty of Zaragoza 1525. Comparative molecular similarity indices CoMSIA is an important extension to CoMFA.
Complex topological indices are created by performing specific operations to an adjacency matrix that allow for the encoding of more complex constitutional information. We describe some recent studies to highlight the success of high-resolution docking in identifying therapeutically important compounds.
For example, the simplest fingerprint may contain the information that a given compound contains six carbon atoms and six hydrogen atoms. In the 1960s, and others began to establish QSAR models using various molecular descriptors to physical, chemical, and biologic properties focused on providing computational estimates for the bioactivity of molecules.
who had in 1871 succeeded in finding and rescuing Livingstone originating the famous line "Dr. He attempted to create the first permanent European settlement in North America at Cap-Rouge Quebec City in 1541 with 400 settlers, but the settlement was abandoned the next year. However, flexible docking methods are still needed for refinement and optimization of poses obtained from an initial rigid docking procedure. reproduced a cryptic drug binding site in an explicit-solvent MD simulations of unliganded p38 mitogen-activated protein kinase p38 MAPK protein, a target in the treatment of inflammatory diseases.
Docking studies with kinases, however, indicate that similarity of binding site influences docking prediction. RCS was also successfully used in identifying low micromolar inhibitors of T. In other words, it creates a frequency plot for a specific range of atom pair distances. In 1498, Columbus left port with a fleet of six ships. There were still significant explorations which occurred well into the modern age. Ligands are thought to interact with some conformations but not others, thus stabilizing conformational populations in the ensemble.
For the linking strategy, several fragments placed at different locations on the target protein serve as seed structure. This compound is identical to compound 1 in I but was discovered using structure-based virtual high-throughput screening. It was only after 1665 that France gave its American colonies the proper means to develop population colonies comparable to that of the British.
Pharmacophore Model A pharmacophore model of the target binding site summarizes steric and electronic features needed for optimal interaction of a ligand with a target.